• Biocatalytic Asymmetric Phosphorylation Catalyzed by Recombinant Glycerate-2-Kinase
  • Biocatalytic Asymmetric Phosphorylation Catalyzed by Recombinant Glycerate-2-Kinase

    Quicker and cleaner: Recombinant glycerate-2-kinase from T. maritima showed excellent selectivity towards phosphorylation of the d-enantiomer of glyceric acid, with no phosphorylation of the l-enantiomer. This straightforward phosphorylation reaction and subsequent product isolation enables the central glycolytic metabolite d-glycerate 2-phosphate to be prepared in fewer reaction steps and with higher purity than chemical routes.

    [Full Papers]
    Dr. Norman Hardt, Birhanu M. Kinfu, Dr. Jennifer Chow, Dr. Bernhard Schoenenberger, Prof. Wolfgang R. Streit, Dr. Markus Obkircher and Dr. Roland Wohlgemuth
    ChemBioChem, https://doi.org/10.1002/cbic.201700201. Read article.



  • Compression of 1,ω-Diammonio-oligo(ethylene glycol) Chains within the “Pyrene Box”
  • Compression of 1,ω-Diammonio-oligo(ethylene glycol) Chains within the “Pyrene Box”

    We present encapsulation and compression mechanisms of 1,ω-diammonio-oligo(ethylene glycols) confined within a pyrene box. The exact coiling behaviour, determined by atomic resolution X-ray diffraction, shows intramolecular hydrogen-bonded, S-shaped conformations of the OEG chains in compressed states.

    [Full Papers]
    Dan G. Dumitrescu, Wei-Xu Feng, Yves-Marie Legrand, Eddy Petit, Arie van der Lee and Mihail Barboiu
    Eur. J. Org. Chem. 2017, 3282. Read article.



  • Superior Alkylating Agents for Bulky Esters/Ketones via Strontium-Mediated Barbier-Type Reaction
  • Superior Alkylating Agents for Bulky Esters/Ketones via Strontium-Mediated Barbier-Type Reaction

    An efficient method has been developed for the Barbier-type alkylation by using alkyl iodide and metallic strontium. The reaction proceeds smoothly at ambient temperature to afford fully alkylated alcohols in better yields than those obtained when using the corresponding Grignard reagents.

    [Communications]
    Dr. Satoshi D. Ohmura, Yasuaki Miyazaki, Daisuke Kanehiro, Yuka Yamaguchi, Saki Kitakata, Sawa Tateda, Takahiro Nishizawa, Ryosuke Shimoda, Gen Nagaoka, Dr. Masaharu Ueno and Prof. Dr. Norikazu Miyoshi
    Asian J. Org. Chem., https://doi.org/10.1002/ajoc.201700209. Read article.



  • A Molecular Turnstile as an E-Field-Triggered Single-Molecule Switch: Concept and Synthesis
  • A Molecular Turnstile as an E-Field-Triggered Single-Molecule Switch: Concept and Synthesis

    Like in an old mechanical electrical switch, an applied E-field is used to trigger an intramolecular rotation in the turnstile structure, thereby altering its electronic transparency. The switching mechanism of the turnstile model compound reported here is not only in the focus of interest as an electronic switch, but also as a single-molecule mechanical molecular machinery experiment.

    [Full Papers]
    Loïc Le Pleux, Elisabeth Kapatsina, Julia Hildesheim, Daniel Häussinger and Marcel Mayor
    Eur. J. Org. Chem. 2017, 3165. Read article.



  • Exploring Non-obvious Hydrophobic Binding Pockets on Protein Surfaces: Increasing Affinities in Peptide–Protein Interactions
  • Exploring Non-obvious Hydrophobic Binding Pockets on Protein Surfaces: Increasing Affinities in Peptide–Protein Interactions

    Not always the answer to life, the universe and everything: Replacing naturally occurring hydrophobic amino acid residues with l-2-aminooctanoic acid increases affinity for target proteins and thus enabled a 42-mer peptide to be “downsized” to an undecamer. Such conjugates provide opportunities to optimize peptides and small organic compounds in biotechnology and biomedicine.

    [Full Papers]
    Aleksandra Balliu and Prof. Lars Baltzer
    ChemBioChem, https://doi.org/10.1002/cbic.201700048. Read article.



  • Coinage Metal Complexes of Phosphonite Analogues of 2-Diphenylphosphino-1,1′-binaphthyl (H-MOP) and 2-Diphenylphosphino-2′-methoxy-1,1′-binaphthyl (MeO-MOP)
  • Coinage Metal Complexes of Phosphonite Analogues of 2-Diphenylphosphino-1,1′-binaphthyl (H-MOP) and 2-Diphenylphosphino-2′-methoxy-1,1′-binaphthyl (MeO-MOP)

    In this paper we have prepared copper, silver and gold complexes of six MOP phosphonites and we have used extensive X-ray crystallographic and NMR spectroscopic studies to characterise them. Any metal–π arene interactions – implicated in several catalytic studies with the coinage metals – would appear to be weak in these systems.

    [Full Papers]
    James T. Fleming, Paul G. Waddell, Michael R. Probert, William Clegg and Lee J. Higham
    Eur. J. Inorg. Chem. 2017, 2837. Read article.



  • Porous Peptide Complexes by a Folding-and-Assembly Strategy
  • Porous Peptide Complexes by a Folding-and-Assembly Strategy

    Fold up your peptide: A new porous peptide structure was constructed from a Gly-Pro-Pro tripeptide ligand and AgI ions by a coordination-driven folding-and-assembly strategy. The 1.5 nm-sized pores were modified with various functional groups while retaining the folded peptide helical structure.

    [Communications]
    Dr. Tomohisa Sawada, Motoya Yamagami, Shuji Akinaga, Tatsuki Miyaji and Prof. Makoto Fujita
    Chem. Asian J., https://doi.org/10.1002/asia.201700458. Read article.



  • Fluorogenic Sensing of Carcinogenic Bisphenol A using Aptamer-Capped Mesoporous Silica Nanoparticles
  • Fluorogenic Sensing of Carcinogenic Bisphenol A using Aptamer-Capped Mesoporous Silica Nanoparticles

    A new hybrid aptamer-capped mesoporous silica material has been developed for the selective and sensitive detection of Bisphenol A in water.

    [Communications]
    Àngela Ribes, Dr. Elena Aznar, Dr. Andrea Bernardos, Dr. M. Dolores Marcos, Dr. Pedro Amorós, Dr. Ramón Martínez-Máñez and Dr. Félix Sancenón
    Chem. Eur. J., https://doi.org/10.1002/chem.201701024. Read article.



  • Electrospun CuO Nanofibers: Stable Nanostructures for Solar Water Splitting
  • Electrospun CuO Nanofibers: Stable Nanostructures for Solar Water Splitting

    Feeling the heat: CuO nanofibers were prepared by electrospinning and the photoelectrochemical properties for fibers prepared at different calcination temperatures were compared. With increasing temperature, the photoresponse and photostability of the fibrous CuO photocathodes improved significantly as a result of enhanced crystallinity and a decreased number of structural defects.

    [Articles]
    Marcus Einert, Tobias Weller, Dr. Thomas Leichtweiß, Prof. Dr. Bernd M. Smarsly and Dr. Roland Marschall
    ChemPhotoChem, https://doi.org/10.1002/cptc.201700050. Read article.



  • Electrosynthesis of Bifunctional WS3−x/Reduced Graphene Oxide Hybrid for Hydrogen Evolution Reaction and Oxygen Reduction Reaction Electrocatalysis
  • Electrosynthesis of Bifunctional WS3−x/Reduced Graphene Oxide Hybrid for Hydrogen Evolution Reaction and Oxygen Reduction Reaction Electrocatalysis

    A trick or two: Bifunctional electrocatalysts of WS3−x supported on reduced graphene oxide (rGO) towards both hydrogen evolution and oxygen reduction reactions (HER and ORR, respectively) are fabricated through simultaneous electrochemical reduction and deposition, as an environmentally benign alternative to conventional fabrication techniques (see figure).

    [Full Papers]
    Shu Min Tan and Prof. Martin Pumera
    Chem. Eur. J. 2017, 23, 8510. Read article.



  • Synthesis of 3-Benzylated Isoindolinones by Photoredox Decarboxylation of Arylacetates in the Presence of N-Benzylphthalimide: Conductivity as a Kinetic Tool
  • Synthesis of 3-Benzylated Isoindolinones by Photoredox Decarboxylation of Arylacetates in the Presence of N-Benzylphthalimide: Conductivity as a Kinetic Tool

    Quest for the rate-determining step: The in situ measurement of conductivity is a powerful tool for kinetic analysis of photoredox-driven alkylations. Acceptor-group-substituted arylacetates are more reactive in the photodecarboxylation/benzylation sequence with N-benzylphthalimide, indicating that primary electron transfer is the rate-determining step.

    [Articles]
    Prof. Dr. Axel G. Griesbeck, Dr. Jörg.-M. Neudörfl, Prof. Dr. Bernd Goldfuss and Dr. Sabrina Molitor
    ChemPhotoChem, https://doi.org/10.1002/cptc.201700057. Read article.



  • Structural Insights into the Recognition of N2-Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14
  • Structural Insights into the Recognition of N2-Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14

    Crystal structures of nucleotide excision repair factor XPA/Rad14 in complex with C8-aryl and N2-acetyl-aryl-dG DNA gave insights into the interactions. Binding of two Rad14 molecules to the lesion site induces a kink in the DNA and recruits the repair mechanism. XPA/Rad14 thus acts as a duplex flexibility sensor.

    [Communications]
    Charlotte Ebert, Nina Simon, Dr. Sabine Schneider and Prof. Dr. Thomas Carell
    ChemBioChem, https://doi.org/10.1002/cbic.201700169. Read article.



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