• Synthesis of a Chiral Borate Counteranion, Its Trityl Salt, and Application Thereof in Lewis-Acid Catalysis
  • Synthesis of a Chiral Borate Counteranion, Its Trityl Salt, and Application Thereof in Lewis-Acid Catalysis

    Chiral modification of the popular perfluorinated borate counteranion [B(C6F5)4] resulted in an air- and water-stable, potentially weakly coordinating borate with various countercations. Its utility is shown in trityl-cation-catalyzed Diels–Alder reactions and a Mukaiyama aldol addition.

    [Full Papers]
    Phillip Pommerening, Jens Mohr, Jonas Friebel and Martin Oestreich
    Eur. J. Org. Chem., https://doi.org/10.1002/ejoc.201700239. Read article.



  • Molecular Tweezers Inhibit PARP-1 by a New Mechanism
  • Molecular Tweezers Inhibit PARP-1 by a New Mechanism

    A molecular-dynamics (MD) simulation of the putative complex between zinc finger FII (PARP-1, poly[ADP-ribose]polymerase 1) and a molecular tweezers ligand reveals a new noncompetitive inhibition mechanism with reference to the substrate: note the simultaneous inclusion of Lys-70 inside the tweezers cavity with coordination at the Zn2+ ion.

    [Full Papers]
    Constanze Wilch, Peter Talbiersky, Utta Berchner-Pfannschmidt, Torsten Schaller, Michael Kirsch, Frank-Gerrit Klärner and Thomas Schrader
    Eur. J. Org. Chem., https://doi.org/10.1002/ejoc.201601596. Read article.



  • Irreversible Bleaching of Donor–Acceptor Stenhouse Adducts on the Surfaces of Magnetite Nanoparticles
  • Irreversible Bleaching of Donor–Acceptor Stenhouse Adducts on the Surfaces of Magnetite Nanoparticles

    Vanish away: Donor–acceptor Stenhouse adducts have been designed to bind strongly to magnetite nanoparticles. Once within a dense monolayer on the nanoparticle surface, the molecules undergo an irreversible decoloration reaction.

    [Articles]
    Dr. Johannes Ahrens, Dr. Tong Bian, Tom Vexler and Dr. Rafal Klajn
    ChemPhotoChem, https://doi.org/10.1002/cptc.201700009. Read article.



  • Conformational Behaviour of Azasugars Based on Mannuronic Acid
  • Conformational Behaviour of Azasugars Based on Mannuronic Acid

    Conformation-specific targeted inhibition: Mannuronic acid azasugars can undergo a conformational change from the conventional 4C1 to the 1C4 chair form upon protonation. This behaviour was shown to be dependent on the functionality at C5. Binding has been studied with a GH47 mannosidase that employs a hydrolysis itinerary proceeding through a 3H4 transition state.

    [Full Papers]
    Dr. Erwin R. van Rijssel, Antonius P. A. Janssen, Alexandra Males, Prof. Dr. Gideon J. Davies, Prof. Dr. Gijsbert A. van der Marel, Prof. Dr. Herman S. Overkleeft and Dr. Jeroen D. C. Codée
    ChemBioChem, https://doi.org/10.1002/cbic.201700080. Read article.



  • Nanostructured Multilayer Films Assembled from Poly(dopamine)-Coated Carbon Nanotubes for Controlling Cell Behavior
  • Nanostructured Multilayer Films Assembled from Poly(dopamine)-Coated Carbon Nanotubes for Controlling Cell Behavior

    Caught on film: A multilayer film with nano-topographic surface is fabricated through layer-by-layer assembly of poly(dopamine)-coated carbon nanotubes (CNTs@PDA) and poly(l-lysine) (PLL). The adhesion and proliferation of endothelial cells, smooth muscle cells, and pheochromocytoma cells on the PLL/CNTs@PDA film were followed and compared.

    [Full Papers]
    Bo-chao Li, Dr. Ke-feng Ren, He Zhang, Fan Jia, Jin-lei Wang, Dr. Hao Chang, Prof. Yun-bing Wang and Prof. Jian Ji
    ChemNanoMat, https://doi.org/10.1002/cnma.201700024. Read article.



  • DNA-Targeted Inhibition of MGMT
  • DNA-Targeted Inhibition of MGMT

    A Zn–porphyrin complex, Zn-DIGPor, binds to DNA and protects O6-methylguanine from the DNA repair enzyme O6-methylguanine-DNA methyltransferase. Zn-DIGPor succeeded in potentiating the effects of the anticancer drug temozolomide in an MGMT-expressing cell line. This represents the first example of DNA-targeted MGMT inhibition.

    [Communications]
    Theodor Marsoner, Olivia P. Schmidt, Therese Triemer and Prof. Dr. Nathan W. Luedtke
    ChemBioChem, https://doi.org/10.1002/cbic.201600652. Read article.



  • Concentration of Nitric Acid Strongly Influences Chemical Composition of Graphite Oxide
  • Concentration of Nitric Acid Strongly Influences Chemical Composition of Graphite Oxide

    Tuneable graphite oxide: Changing the nitric acid concentration in the synthesis of graphite oxide allows a continuous change in its composition. Samples are prepared using various nitric acid concentrations (see figure), and are investigated through various spectroscopic and analytical methods. With lower concentrations of nitric acid required, the overall cost of graphite oxide synthesis may be reduced significantly.

    [Full Papers]
    Dr. Ondřej Jankovský, Michal Nováček, Jan Luxa, Prof. David Sedmidubský, Marie Boháčová, Prof. Martin Pumera and Prof. Zdeněk Sofer
    Chem. Eur. J., https://doi.org/10.1002/chem.201700809. Read article.



  • Easy Access to SCF2-Containing Molecules through a Versatile Reagent
  • Easy Access to SCF2-Containing Molecules through a Versatile Reagent

    A fluoroalkylmethanesulfenamide reagent was developed to synthesize various molecules bearing the SCF2CO2Me group. Furthermore, the carboxyl function is successfully post-transformed, through C–C coupling, for easy access to molecules containing the –SCF2– functionality.

    [Communications]
    Ermal Ismalaj, Quentin Glenadel and Thierry Billard
    Eur. J. Org. Chem. 2017, 1911. Read article.



  • Sequential Functionalization of a Natural Crosslinker Leads to Designer Silicone Networks
  • Sequential Functionalization of a Natural Crosslinker Leads to Designer Silicone Networks

    Great combinations: Sequential reactions of eugenol with different H-terminated silicones permit precise foam and elastomer 3D structures to be assembled in one pot using combinations of the Piers–Rubinsztajn reaction and platinum-catalyzed hydrosilylation.

    [Communications]
    Scott E. Laengert, Alyssa F. Schneider, Eric Lovinger, Yang Chen and Prof. Michael A. Brook
    Chem. Asian J., https://doi.org/10.1002/asia.201700160. Read article.



  • Aluminum Alkali Metalate Derivatives: Factors Driving the Final Nuclearity in the Crystal Form
  • Aluminum Alkali Metalate Derivatives: Factors Driving the Final Nuclearity in the Crystal Form

    Reaction of [M(OR)]6 (M = Li, Na, K) with different aluminum precursors leads to aluminates with an Al2M2 or Al3M3 core. To rationalize the driving forces directing the final nuclearity, DFT calculations have been performed.

    [Full Papers]
    M. Teresa Muñoz, Gotzone Barandika, Begoña Bazán, Tomás Cuenca and Marta E. G. Mosquera
    Eur. J. Inorg. Chem. 2017, 1994. Read article.



  • Highly Electron-Rich β-Diketiminato Systems: Synthesis and Coordination Chemistry of Amino-Functionalized “N-nacnac” Ligands
  • Highly Electron-Rich β-Diketiminato Systems: Synthesis and Coordination Chemistry of Amino-Functionalized “N-nacnac” Ligands

    Nacnac, who′s there: The synthesis and coordination chemistry of electron-rich amino-functionalized β-diketiminato (N-nacnac) ligands are reported. Two synthetic methodologies have been developed for protio-ligands bearing backbone NR2 groups, which react with metal alkyls to access complexes from groups 1, 2, and 13. SnII and YbII systems can be prepared through transmetalation to allow direct comparison with conventional Nacnac compounds.

    [Full Papers]
    Dinh Cao Huan Do, Ailsa Keyser, Dr. Andrey V. Protchenko, Dr. Brant Maitland, Dr. Indrek Pernik, Haoyu Niu, Dr. Eugene L. Kolychev, Dr. Arnab Rit, Dr. Dragoslav Vidovic, Dr. Andreas Stasch, Prof. Cameron Jones and Prof. Simon Aldridge
    Chem. Eur. J., https://doi.org/10.1002/chem.201700757. Read article.



  • Supramolecular Assembly of 1D Pristine Carbon Nanotubes and 2D Graphene Oxides into Macroscopic All-Carbon Hybrid Sponges for High-Energy-Density Supercapacitors
  • Supramolecular Assembly of 1D Pristine Carbon Nanotubes and 2D Graphene Oxides into Macroscopic All-Carbon Hybrid Sponges for High-Energy-Density Supercapacitors

    All-carbon hybrid aerogels consisting of pristine carbon nanotubes (CNTs) and graphene oxide (GO) have been prepared using an extremely simple approach. The potential use of such three-dimensional all-carbon aerogels with net-like porous carbon walls as a promising electrode material for supercapacitors has also been demonstrated.

    [Full Papers]
    Kening Wan, Siliang Liu, Dr. Chao Zhang, Le Li, Zhe Zhao, Prof. Tianxi Liu and Prof. Yi Xie
    ChemNanoMat, https://doi.org/10.1002/cnma.201700037. Read article.



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