• Metal-Containing Polymers as Light-Emitting and Light-Responsive Materials and Beyond
  • Metal-Containing Polymers as Light-Emitting and Light-Responsive Materials and Beyond

    Functional materials that respond to external stimuli are of major current interest. Supramolecular systems that can interact with their surroundings, adapt to the environmental changes and evolve with are even more fascinating, yet challenging. A judicious combination of multi-topic organic ligands with metal centres affords functional and light-responsive metal-containing polymers that possess widespread potential application.

    [Concepts]
    Dr. Matteo Mauro, Dr. Stéphane Bellemin-Laponnaz and Dr. Cristina Cebrián
    Chem. Eur. J., https://doi.org/10.1002/chem.201702936. Read article.



  • Liquid Hydrocarbon Production from CO2: Recent Development in Metal-Based Electrocatalysis
  • Liquid Hydrocarbon Production from CO2: Recent Development in Metal-Based Electrocatalysis

    Liquid assets: The electrochemical reduction of CO2 into high-value liquid organic products could be of vital importance to mitigate rising CO2 levels in the atmosphere. The conversion of CO2 into liquid fuels by using photovoltaic cells, which can readily be integrated in the current infrastructure, will help realize the creation of a sustainable cycle of carbon-based fuel that will promote zero net CO2 emissions.

    [Minireviews]
    Rahman Daiyan, Dr. Xunyu Lu, Dr. Yun Hau Ng and Prof. Rose Amal
    ChemSusChem, https://doi.org/10.1002/cssc.201701631. Read article.



  • Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds
  • Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds

    Cascades in cells: A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds through in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase-mediated C−C bond formation is investigated. The optimized whole-cell catalyst, combined with a refined solid-phase extraction downstream purification protocol gives optically pure aldol products.

    [Full Papers]
    DI Thomas Wiesinger, Dr. Thomas Bayer, Dr. Sofia Milker, Prof. Marko D. Mihovilovic and Dr. Florian Rudroff
    ChemBioChem, https://doi.org/10.1002/cbic.201700464. Read article.



  • Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis
  • Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis

    Engineering an (Ir)regular cytochrome P450: Mutations within the heme-binding pocket of a cytochrome P450 enabled the selective incorporation of an artificial Ir-porphyrin cofactor into the protein, in cells. This orthogonal metalloprotein showed enhanced behavior in unnatural carbene-mediated cyclopropanation of aliphatic and electron-deficient olefins.

    [Communications]
    Dr. Evan W. Reynolds, Timothy D. Schwochert, Matthew W. McHenry, John W. Watters and Prof.Dr. Eric M. Brustad
    ChemBioChem, https://doi.org/10.1002/cbic.201700397. Read article.



  • Different and Often Opposing Forces Drive the Encapsulation and Multiple Exterior Binding of Charged Guests to a M4L6 Supramolecular Vessel in Water
  • Different and Often Opposing Forces Drive the Encapsulation and Multiple Exterior Binding of Charged Guests to a M4L6 Supramolecular Vessel in Water

    The driving forces for the encapsulation and exterior binding of quaternary ammonium guests to the [Ga4L6]12− assembly in water are discussed. Encapsulation into the host cavity is always an entropy-driven process, whereas exterior ion-association strongly depends on guest size and character. The energetics of guest binding may help understanding the role of the transition state in rate accelerated reactions promoted by this molecular flask (see scheme).

    [Full Papers]
    Dr. Carmelo Sgarlata, Dr. Jeffrey S. Mugridge, Dr. Michael D. Pluth, Valeria Zito, Prof. Giuseppe Arena and Prof. Kenneth N. Raymond
    Chem. Eur. J., https://doi.org/10.1002/chem.201703202. Read article.



  • Vacuum-Deposited versus Spin-Coated Emissive Layers for Fabricating High-Performance Blue–Green-Emitting Diodes
  • Vacuum-Deposited versus Spin-Coated Emissive Layers for Fabricating High-Performance Blue–Green-Emitting Diodes

    Nature adores a vacuum: Blue–green-emitting diodes based on sublimable cationic iridium(III) complexes display higher performance when the emissive layers (EMLs) are vacuum-deposited rather than spin-coated (see figure).

    [Communications]
    Dr. Dongxin Ma, Prof. Yong Qiu and Prof. Lian Duan
    ChemPlusChem, https://doi.org/10.1002/cplu.201700382. Read article.



  • AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker
  • AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker

    Crosslinks and conjugation: O6-Alkylguanine DNA alkyltransferases (AGTs) can act on O6-alkyl 2′-deoxyguanosine and O4-alkyl thymidine DNA lesions. We show the ability of the human AGT to efficiently repair intrastrand crosslinks, which can be used to generate covalent complexes. We synthesized IaCL DNA with ethylene or propylene linkages, with the latter being moderately repaired by human AGT.

    [Full Papers]
    Dr. Derek K. O'Flaherty and Prof. Dr. Christopher J. Wilds
    ChemBioChem, https://doi.org/10.1002/cbic.201700450. Read article.



  • Palladium Complexes of Carbazole-Based Chalcogenaisophlorins: Synthesis, Structure, and Solid-State NIR Absorption Spectra
  • Palladium Complexes of Carbazole-Based Chalcogenaisophlorins: Synthesis, Structure, and Solid-State NIR Absorption Spectra

    Don't hesitate, metalate! Palladium complexes of carbazole-based isophlorins (see figure) were synthesized. Metalation planarized the structures and generated antiaromatic character. The complexes showed weak near-infrared (NIR) absorption in solution. In addition, the sulfur- and selenium-based complexes formed trimeric and dimeric stacked layered structures, respectively, and showed relatively strong NIR absorption in the solid state.

    [Communications]
    Dr. Chihiro Maeda, Dr. Kazuto Takaishi and Prof. Tadashi Ema
    ChemPlusChem, https://doi.org/10.1002/cplu.201700430. Read article.



  • Bis-Acetyl Carbazole: A Photoremovable Protecting Group for Sequential Release of Two Different Functional Groups and Its Application in Therapeutic Release
  • Bis-Acetyl Carbazole: A Photoremovable Protecting Group for Sequential Release of Two Different Functional Groups and Its Application in Therapeutic Release

    Bis-acetyl carbazole-based fluorescent photoremovable protecting groups (FPRPG) have been synthesized and used for the sequential release of two different functional groups such as carboxylic acids, alcohols, thiols, and amines. Studies on a synthesized drug delivery system (DDS) demonstrated the applicability of the dual release ability of our system in vitro.

    [Full Papers]
    Yarra Venkatesh, Surajit Nandi, Maniklal Shee, Biswajit Saha, Anakuthil Anoop and N. D. Pradeep Singh
    Eur. J. Org. Chem. 2017, 6121. Read article.



  • Doping or Deposition of NiS on Cd0.3Zn0.7S Photocatalysts: Optimising Photocatalytic Hydrogen Evolution
  • Doping or Deposition of NiS on Cd0.3Zn0.7S Photocatalysts: Optimising Photocatalytic Hydrogen Evolution

    Doping is better! Two series of Cd0.3Zn0.7S samples, one in which the bulk was doped with NiS and the other with NiS deposited on the catalyst surface, were prepared. The photocatalysts doped with NiS are more active as a result of new additional energy levels in its band structure (see picture) which can improve photoinduced charge separation and hydrogen photoproduction.

    [Articles]
    Dina V. Markovskaya, Dr. Ekaterina A. Kozlova, Dr. Svetlana V. Cherepanova, Dr. Pavel A. Kolinko, Dr. Eugeny Yu. Gerasimov and Dr. Valentin N. Parmon
    ChemPhotoChem, https://doi.org/10.1002/cptc.201700121. Read article.



  • Synthesis of Naphthyridine Dimers with Conformational Restriction and Binding to DNA and RNA
  • Synthesis of Naphthyridine Dimers with Conformational Restriction and Binding to DNA and RNA

    Get in there! Mismatch binding ligands (MBLs) composed of two heterocycles joined by short linkers to restrict conformational changes are investigated for their ability to bind to DNA and RNA, as revealed by conformation analysis and experimental results (see figure). The effects of solvent on stacked or unstacked conformations of MBLs are also revealed.

    [Full Papers]
    Prof. Dr. Kazuhiko Nakatani, Nozomi Natsuhara, Yuki Mori, Dr. Sanjukta Mukherjee, Dr. Bimolendu Das and Prof. Dr. Asako Murata
    Chem. Asian J., https://doi.org/10.1002/asia.201701293. Read article.



  • Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma
  • Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

    The fungus among us: The cyclization mechanism of the bioactive, unique, tetracyclic diterpene harzianone, produced by the biocontrol fungus Trichoderma, was studied by feeding experiments using synthetic mevalonolactone isotopologues. Results were captured with a closed-loop stripping apparatus (CLSA) and directly analyzed by 13C NMR spectroscopic methods.

    [Full Papers]
    Lena Barra and Prof. Dr. Jeroen S. Dickschat
    ChemBioChem, https://doi.org/10.1002/cbic.201700462. Read article.



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