• Increase in the β-Sheet Character of an Amyloidogenic Peptide upon Adsorption onto Gold and Silver Surfaces
  • Increase in the β-Sheet Character of an Amyloidogenic Peptide upon Adsorption onto Gold and Silver Surfaces

    All on the surface? Fibrillation of amyloidogenic peptides is believed to be the cause of neurodegenerative diseases. Atomistic molecular dynamics simulations are used to show that adsorption of Aβ25–35 onto silver and gold surfaces catalyzes the formation of β-sheet-rich conformations of Aβ25–35. This study suggests that the interactions at the nano–bio interface prompts the toxicity of this peptide by altering its conformational state.

    [Articles]
    Nima Soltani and Prof. Mohammad Reza Gholami
    ChemPhysChem, doi: 10.1002/cphc.201601000. Read article.



  • Rationalising Heteronuclear Decoupling in Refocussing Applications of Solid-State NMR Spectroscopy
  • Rationalising Heteronuclear Decoupling in Refocussing Applications of Solid-State NMR Spectroscopy

    Rational decoupling: Factors affecting the performance of decoupling sequences for solid-state NMR spectroscopy are investigated and rationalised over a wide range of experimental conditions, including (as shown) the very high radio-frequency nutation rates achievable by using microcoils.

    [Articles]
    Dr. Ilya Frantsuzov, Dr. Suresh K. Vasa, Prof. Dr. Matthias Ernst, Prof. Steven P. Brown, Dr. Vadim Zorin, Prof. Dr. Arno P. M. Kentgens and Dr. Paul Hodgkinson
    ChemPhysChem, doi: 10.1002/cphc.201601003. Read article.



  • Selective Hydrogenation of Nitriles to Primary Amines by using a Cobalt Phosphine Catalyst
  • Selective Hydrogenation of Nitriles to Primary Amines by using a Cobalt Phosphine Catalyst

    Cobalt catalyzes it: A general procedure for the selective hydrogenation of (hetero)aromatic or aliphatic nitriles catalyzed by a cobalt-based system is described. A wide range of primary amines are synthesized in 61–99 % yield. Use of the tetradentate ligand tris[2-(dicyclohexylphosphino)ethyl]phosphine is key for the activity of the system.

    [Communications]
    Dr. Rosa Adam, Dr. Charles Beromeo Bheeter, Dr. Jose R. Cabrero-Antonino, Dr. Kathrin Junge, Dr. Ralf Jackstell and Prof. Matthias Beller
    ChemSusChem, doi: 10.1002/cssc.201601843. Read article.



  • Direct Synthesis of Renewable Dodecanol and Dodecane with Methyl Isobutyl Ketone over Dual-Bed Catalyst Systems
  • Direct Synthesis of Renewable Dodecanol and Dodecane with Methyl Isobutyl Ketone over Dual-Bed Catalyst Systems

    Dual-bed catalysis: For the first time, dodecanol and jet fuel range C12-branched alkane (2,4,8-trimethylnonane) are directly synthesized with high carbon yield (∼70 %) by using dual-bed catalyst systems with hydrogen and methyl isobutyl ketone (MIBK) that can be derived from lignocellulose.

    [Communications]
    Dr. Xueru Sheng, Prof. Ning Li, Prof. Guangyi Li, Prof. Wentao Wang, Prof. Aiqin Wang, Prof. Yu Cong, Prof. Xiaodong Wang and Prof. Tao Zhang
    ChemSusChem, doi: 10.1002/cssc.201601563. Read article.



  • Expanding Water/Base Tolerant Frustrated Lewis Pair Chemistry to Alkylamines Enables Broad Scope Reductive Aminations
  • Expanding Water/Base Tolerant Frustrated Lewis Pair Chemistry to Alkylamines Enables Broad Scope Reductive Aminations

    Basically” different: BPh3 has a higher tolerance to H2O and alkylamine combinations than B(C6F5)3, due to the lower Brønsted acidity of H2O–BPh3. This extends the water/base tolerance of FLP systems to strong bases (conjugate acid pKa=18.5). With weaker amine bases H2O-BPh3 undergoes proto-deboronation. B(3,5-Cl2C6H3)3, a borane of intermediate Lewis acidity, was shown to be effective for the reductive amination of a range of amines whose conjugate acids span pKa values of 10.6 to 18.5 in MeCN.

    [Full Papers]
    Valerio Fasano and Dr. Michael J. Ingleson
    Chem. Eur. J. 2017, 23, 2217. Read article.



  • Organic Multilayer Films Studied by Scanning Tunneling Microscopy
  • Organic Multilayer Films Studied by Scanning Tunneling Microscopy

    See beyond the layers: The growth of organic thin films on various electrodes is of crucial importance for organic electronics. Scanning tunneling microscopy studies on the growth modes of self-assembled multilayer films on metallic surfaces (see figure), the electronic states of the individual molecules in the layers, and the manipulation of spin states in spin-crossover compounds embedded in multilayers are reviewed.

    [Minireviews]
    Dr. Yang He, Prof. Jörg Kröger and Prof. Yongfeng Wang
    ChemPhysChem, doi: 10.1002/cphc.201600979. Read article.



  • Pore Topology Effects in Positron Annihilation Spectroscopy of Zeolites
  • Pore Topology Effects in Positron Annihilation Spectroscopy of Zeolites

    The behavior of ortho-positronium in zeolitic materials is highly sensitive to the micropore topology. An atomic model is developed based on the Tao–Eldrup potential and the crystallographic structure to calculate the inherent distribution and lifetime of ortho-positronium for a given framework type.

    [Articles]
    Dr. Asier Zubiaga, Dr. Robbie Warringham, Dr. Sharon Mitchell, Lars Gerchow, Dr. David Cooke, Dr. Paolo Crivelli and Prof. Javier Pérez-Ramírez
    ChemPhysChem, doi: 10.1002/cphc.201601258. Read article.



  • Precipitation and Crystallization Kinetics in Silica Gardens
  • Precipitation and Crystallization Kinetics in Silica Gardens

    How the garden grows: The kinetics of coupled dissolution and precipitation/crystallization processes in self-assembled silica-garden structures are elucidated by means of synchrotron X-ray diffraction and X-ray absorption spectroscopy (XAS; see figure). A kinetic model is proposed to describe the relevant reactions on a fundamental physicochemical level.

    [Articles]
    Dr. Fabian Glaab, Julian Rieder, Dr. Regina Klein, Dr. Duane Choquesillo-Lazarte, Dr. Emilio Melero-Garcia, Prof. Juan-Manuel García-Ruiz, Prof. Werner Kunz and Dr. Matthias Kellermeier
    ChemPhysChem, doi: 10.1002/cphc.201600748. Read article.



  • Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram-Negative Bacteria
  • Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram-Negative Bacteria

    Dihydromotuporamine derivatives were evaluated for their in vitro antibiotic enhancement properties against Gram-negative bacteria. The mechanism of action of derivative MOTU-N44 was investigated: it inhibits the activity of drug transporters by de-energization the efflux pump rather than by direct interaction of the molecule with the pump itself.

    [Full Papers]
    Diane Borselli, Marine Blanchet, Jean-Michel Bolla, Aaron Muth, Kristen Skruber, Dr. Otto Phanstiel IV and Dr. Jean Michel Brunel
    ChemBioChem 2017, 18, 276. Read article.



  • Hexagonal Boron Nitride (h-BN) Sheets Decorated with OLi, ONa, and Li2F Molecules for Enhanced Energy Storage
  • Hexagonal Boron Nitride (h-BN) Sheets Decorated with OLi, ONa, and Li2F Molecules for Enhanced Energy Storage

    First-principles electronic structure calculations are carried out on hexagonal boron nitride (h-BN) sheets functionalized with small molecules, such as OLi, ONa, and Li2F, to study their hydrogen storage properties.

    [Articles]
    Syeda Rabab Naqvi, Dr. Gollu Sankar Rao, Dr. Wei Luo, Prof. Rajeev Ahuja and Dr. Tanveer Hussain
    ChemPhysChem, doi: 10.1002/cphc.201601063. Read article.



  • From Folding to Function: Design of a New Switchable Biosurfactant Protein
  • From Folding to Function: Design of a New Switchable Biosurfactant Protein

    Folding to function: We report a new design of an anionic protein surfactant, SP16, capable of tuning foaming behaviour by pH or salt. The high negative charge at pH 6 and above restrict its ability to fold into an α-helical conformation entailing low foaming propensity, but the presence of salt (NaCl) was found to effectively screen negative charge, thus leading to its folding and the restore of its foaming activity.

    [Articles]
    Dr. Chun-Xia Zhao, Dr. Mirjana Dimitrijev Dwyer, Lei Yu and Prof. Anton P. J. Middelberg
    ChemPhysChem, doi: 10.1002/cphc.201601277. Read article.



  • Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens
  • Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens

    Biofilm busters: We have discovered and evaluated a series of N-arylated NH125 analogues that display potent biofilm-eradicating activity against multiple Gram-positive pathogens and rapidly kill MRSA persister cells in stationary cultures. These analogues are promising new broad-spectrum agents against bacterial resistance.

    [Communications]
    Yasmeen Abouelhassan, Akash Basak, Hussain Yousaf and Prof. Robert W. Huigens III
    ChemBioChem 2017, 18, 352. Read article.



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